If you rely on the .NET Framework 4 (a subset of the full framework), you are in dangerous territory. Visual Studio 2022 dropped support for the Client Profile entirely. You must migrate to the full 4.0 or upgrade to 4.8.
Check the box next to (or the specific minor version you require, such as 4.0, 4.5, 4.6, etc.).
: Starting with .NET Framework 4.5, Microsoft streamlined the multi-targeting experience. The "Developer Pack" for each version (e.g., .NET Framework 4.5.1 Developer Pack) includes both the reference assemblies needed for multi-targeting and the corresponding runtime, simplifying the installation process.