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| Study / Source | Design | Sample Size | Main Findings | |----------------|--------|-------------|----------------| | | Prospective case series | 28 adults with minor anal fissures | 71 % reported pain reduction by day 3; complete healing in 54 % by day 10. | | Independent dermatology review (2025) | Narrative review of topical agents for perianal pruritus | N/A | Concluded that combination products (antimicrobial + steroid) have modest benefit over steroid alone for mixed bacterial‑fungal irritation, but high‑quality RCT data are lacking. | | Pharmacovigilance database (2025‑2026) | Post‑marketing safety monitoring | >1,200 reported uses worldwide | Most adverse events were mild skin irritation; rare systemic reactions (e.g., GI upset) aligned with fluoro‑quinolone profiles. |
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